Synthesis of 2-Amino-4-(2-hydroxynaphthyl)-4H-chromene-3-carbonitriles by Michael Addition and Their Transformation into New Pentacyclic Compounds
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چکیده
منابع مشابه
2-Amino-4-(nitroalkyl)-4H-chromene-3-carbonitriles as New Cytotoxic Agents
A series of 2-amino-4-(nitroalkyl)-4H-chromene-3-carbonitriles were synthesized by an efficient multicomponent reaction in aqueous media using DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) as a catalyst at room temperature. Mild condition, environment friendly procedure and excellent yields are the main advantages of this procedure. The cytotoxic activity of target compounds were evaluated against t...
متن کامل2-Amino-4-(nitroalkyl)-4H-chromene-3-carbonitriles as New Cytotoxic Agents
A series of 2-amino-4-(nitroalkyl)-4H-chromene-3-carbonitriles were synthesized by an efficient multicomponent reaction in aqueous media using DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) as a catalyst at room temperature. Mild condition, environment friendly procedure and excellent yields are the main advantages of this procedure. The cytotoxic activity of target compounds were evaluated against t...
متن کامل2-Amino-4-(nitroalkyl)-4H-chromene-3-carbonitriles as New Cytotoxic Agents
A series of 2-amino-4-(nitroalkyl)-4H-chromene-3-carbonitriles were synthesized by an efficient multicomponent reaction in aqueous media using DBU as a catalyst at room temperature. Mild condition, environment friendly procedure and excellent yields are the main advantages of this procedure. The cytotoxic activity of target compounds were evaluated against three cancer cell lines MDA-MB-231, MC...
متن کامل2-amino-4-(nitroalkyl)-4h-chromene-3-carbonitriles as new cytotoxic agents
a series of 2-amino-4-(nitroalkyl)-4h-chromene-3-carbonitriles were synthesized by an efficient multicomponent reaction in aqueous media using dbu (1,8-diazabicyclo[5.4.0]undec-7-ene) as a catalyst at room temperature. mild condition, environment friendly procedure and excellent yields are the main advantages of this procedure. the cytotoxic activity of target compounds were evaluated against t...
متن کاملFacile and convenient synthesis of 2-amino-5,10-dioxo-4-aryl-5,10-dihydro-4H-benzo[g]chromene-3-carbonitrile derivatives by electrocatalytically chemical transformation
2-Amino-5,10-dioxo-4-aryl-5,10-dihydro-4H-benzo[g]chromene-3-carbonitrile derivatives are obtained in excellent yields with a simple and efficient procedure.This reaction can occur using electrocatalytic multicomponent chain transformation of aryl aldehydes, 2-hydroxynaphthalene-1,4-dione and malononitrile under neutral and mild conditions. Moreover, electrolysis is done in CH3CN as solvent, Te...
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ژورنال
عنوان ژورنال: Synthetic Communications
سال: 2014
ISSN: 0039-7911,1532-2432
DOI: 10.1080/00397911.2014.924142